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生殖医学解决方案 > 1次采样,3种检测!子宫内膜三合一检测 EndomeTRIO

EndomeTRIO: The endometrium matters

A new dimension of endometrial health to improve the reproductive prognosis of your patients.

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

EMMA + ALICE + ERA

A better understanding of endometrial health to improve you patient’s reproductive prognosis

20% of infertility is caused by
the endometrial factor.

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Overview
  • EndomeTRIO
  • Benefits
  • Indications

The endometrium matters

  • Since 2014, IGENOMIX has been conducting a deep line of research to understand the endometrium factor in recurrent implantation failure patients.  
  • Dysbiosis of the uterine cavity has been associated to poor reproductive outcomes in IVF patients, suggesting that pathogenic deviations of the Lactobacillus endometrial content could play a role in infertility (Moreno et al., 2016)

What is the procedure?

What tests are included in EndomeTRIO?

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ERA

Endometrial Receptivity Analysis

  • The ERA test resulted in a 73% pregnancy rate in patients with implantation failure.
More info
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EMMA

Endometrial Microbiome Metagenomic Analysis

  • Our scientific publication ’Evidence that the endometrial microbiota has an effect on implantation success or failure‘, establishes that the pathological modification of endometrial microbiota is associated with poor reproductive outcomes for IVF patients.
More info
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ALICE

Analysis of Infectious Chronic Endometritis

  • Independent studies show that this condition affects up to 30% of infertile patients, and in cases of repeated implantation failure or recurrent pregnancy loss, this can rise to 66%.
More info

Who should use EndomeTRIO Analysis?

  • Women who have experienced implantation failure with morphologically good quality embryos. 
  • Women with a history of recurrent pregnancy loss. 
  • Women with a morphologically normal uterus and normal endometrial thickness (≥ 6 mm), where the uterus and endometrium are unlikely to be the problem. 
  • Women with chronic Endometritis. 

EMMA/ALICE Limitations

  • These tests are not able to detect resistance to antibiotics. 
  • ALICE only detects the presence of pathogens associated with chronic endometritis. A negative result does not rule out the presence of other endometrial pathogens.
  • The tests are not 100% accurate at determining the bacterial species. 

ERA Limitations

  • There is a risk (<5%) to get a non-informative result, in which the biopsy procedure has failed to obtain a sufficient quantity and/or quality of tissue to be able to make a diagnosis. If this should occur a new biopsy will be required.
  • The aim of this test Is to provide physicians with an objective molecular diagnosis of the patient´s endometrial timing of receptivity. Depending on the results of this test, the physician may use it as a guide for personalized embryo transfer.
  • Pregnancy is not guaranteed, even with a receptive result. Poor embryo quality, genetic abnormalities, or previous pathologies can also reduce the likelihood of becoming pregnant.
  • The ERA® does not test for any other endometrial pathology and does not asses or provide a prediction for the health of a subsequent pregnancy. 
Documentation
  • Specialists’ documents

Clinical Sheets

Download

Brochure

Download

Infography

Download

Manual

Download
Scientific evidence

Relevant related studies:

Cicinelli et al. Reprod Sci 2014; 21(5):640-7.

Cicinelli et al. Hum Reprod. 2015; 30(2):323-30. 

Moreno I. et tal. Am J Obstet Gynecol, 2018, 218(6):602-602.

Moreno I. et tal. Am J Obstet Gynecol. 2016;215(6):684-703.

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I’m not a health specialist

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Igenomix提供创新的检测以帮助生殖医学专家解决患者的生殖问题。在患者生殖历程的怀孕前、植入前与生产前的各阶段,为患者提供全面的高质量解决方案

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Other services

ERA
子宫内膜容受性分析

ERA 检测,通过检测采集的样本得知目前子宫内膜的基因图谱,以此确认子宫内膜状态是否具有容受性。

EMMA
子宫内菌群检测

用以评估子宫内膜微生物水平的检测。

ALICE
感染性慢性子宫内膜炎检测

检测引起慢性子宫内膜炎的细菌,以提高您患者的试管婴儿成功率

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Igenomix 在中国的所有检测服务,均由杭州奕真医学检验所有限公司(下文简称“奕真生物”)完成。奕真生物于 2015 年创立,为全中资的独立医学检验所,拥有由资深专家组成的本地基因分析、 解读、和咨询团队, 实验室已获得国家批准的实验室医疗机构执业许可资质,和美国 CAP 和 CLIA 认证(证书见下方)。2019 年 3 月,奕真生物与 Igenomix 宣布战略合作,引入 Igenomix 生殖遗传检测产品线,为中国市场提供辅助生殖基因检测服务。

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