慢性子宫内膜炎检测 ALICE

Overview

ALICE
Benefits
Indications

What is ALICE test?

ALICE is a test that detects pathogenic bacteria and recommends adequate treatment.

Pathogenic bacteria cause chronic endometritis, which is linked to implantation failure and recurrent miscarriage.

In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

What is the procedure?

Why use ALICE test?

ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis., recommending appropriate antibiotic and probiotic treatment.
ALICE microbiology method allows the identification of culturable and nonculturable endometrial pathogens associated with chronic endometritis.
A list with the recommended antibiotics and probiotics will be provided depending on ALICE results.
ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.
If ALICE tests positive, the report will focus on the detection of those the specific bacteria causing said the condition.
Microbiology counseling will be available.

Who should use ALICE test?

ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

Test Limitations

This test are not able to detect resistance to antibiotics.
ALICE only detects the presence of pathogens associated with chronic endometritis. A negative result does not rule out the presence of other endometrial pathogens.
The tests are not 100% accurate at determining the bacterial species.

Documentation & Resources

ALICE Specialists' documents

Relevant related studies:

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14.

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016; 215:684-703.

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C. The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. Am J Obstet Gynecol. 2018, DOI: 10.1016/j.ajog.2018.02.012.